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GENERAL
TITLE
CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN SHOWS COMMON BUT DISTINCT RECOGNITION OF IMMUNOPHILIN-DRUG COMPLEXES
DATE LAST MODIFIED
21 Jul 2021
RELEASE
25 Sept 2002
OBSOLETE
CLASSIFICATION
HYDROLASE/ISOMERASE/IMMUNOSUPPRESSANT
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 41 21 2
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
40
PUBMED ID
DOI
10.1073/PNAS.192206699
PDBe
1M63
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| Q08209 | CNA ALPHA | ESCHERICHIA COLI BL21 | HUMAN | CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA ISOFORM,CAM-PRP SUBUNIT | HUMAN | CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA I ... | Mutations | |
| P63098 | CNB | ESCHERICHIA COLI BL21 | HUMAN | PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTEINPHOSPHATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM 1 | HUMAN | PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTE ... | Mutations | |
| P62937 | -- | ESCHERICHIA COLI BL21 | HUMAN | PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BINDINGPROTEIN | HUMAN | PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BI ... | Mutations | |
| NOR00033 | -- | -- | TOLYPOCLADIUM INFLATUM | CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE | TOLYPOCLADIUM INFLATUM | CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE | ||
| Q08209 | CNA ALPHA | ESCHERICHIA COLI BL21 | HUMAN | CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA ISOFORM,CAM-PRP SUBUNIT | HUMAN | CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA I ... | Mutations | |
| P63098 | CNB | ESCHERICHIA COLI BL21 | HUMAN | PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTEINPHOSPHATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM 1 | HUMAN | PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTE ... | Mutations | |
| P62937 | -- | ESCHERICHIA COLI BL21 | HUMAN | PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BINDINGPROTEIN | HUMAN | PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BI ... | Mutations | |
| NOR00033 | -- | -- | TOLYPOCLADIUM INFLATUM | CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE | TOLYPOCLADIUM INFLATUM | CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402