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GENERAL
TITLE
CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN SHOWS COMMON BUT DISTINCT RECOGNITION OF IMMUNOPHILIN-DRUG COMPLEXES
DATE LAST MODIFIED
21 Jul 2021
RELEASE
25 Sept 2002
OBSOLETE
CLASSIFICATION
HYDROLASE/ISOMERASE/IMMUNOSUPPRESSANT
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 41 21 2
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
40
PUBMED ID
DOI
10.1073/PNAS.192206699

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q08209 CNA ALPHA ESCHERICHIA COLI BL21 HUMAN CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA ISOFORM,CAM-PRP SUBUNIT HUMAN
CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA I ...
Mutations
P63098 CNB ESCHERICHIA COLI BL21 HUMAN PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTEINPHOSPHATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM 1 HUMAN
PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTE ...
Mutations
P62937 -- ESCHERICHIA COLI BL21 HUMAN PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BINDINGPROTEIN HUMAN
PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BI ...
Mutations
NOR00033 -- -- TOLYPOCLADIUM INFLATUM CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE TOLYPOCLADIUM INFLATUM
CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE
Q08209 CNA ALPHA ESCHERICHIA COLI BL21 HUMAN CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA ISOFORM,CAM-PRP SUBUNIT HUMAN
CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA I ...
Mutations
P63098 CNB ESCHERICHIA COLI BL21 HUMAN PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTEINPHOSPHATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM 1 HUMAN
PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTE ...
Mutations
P62937 -- ESCHERICHIA COLI BL21 HUMAN PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BINDINGPROTEIN HUMAN
PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BI ...
Mutations
NOR00033 -- -- TOLYPOCLADIUM INFLATUM CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE TOLYPOCLADIUM INFLATUM
CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402