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GENERAL
TITLE
TMC-95 BASED BIPHENYL-ETHER MACROCYCLES: SPECIFIC PROTEASOME INHIBITORS
DATE LAST MODIFIED
24 Feb 2009
RELEASE
11 Jul 2006
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
15
PUBMED ID
DOI
10.1016/J.CHEMBIOL.2006.04.005
PDBe
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LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P30657 PRE4 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT PRE4, PROTEINASE YSCE SUBUNITPRE ...
Mutations
P38624 PRE3 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT PRE3, PROTEINASE YSCE SUBUNITPRE ...
Mutations
P38684 PRS4, PRE8 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT Y7, PROTEINASE YSCE SUBUNIT 7,MU ...
P00829 PRS5, PRE9 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT Y13, PROTEINASE YSCE SUBUNIT 13, ...
P0A953 PRE6 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT PRE6, PROTEINASE YSCE SUBUNITPRE ...
P50502 PUP2, DOA5 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT PUP2, PROTEINASE YSCE SUBUNITPUP ...
Q9UKV8 PRE5 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT PRE5, PROTEINASE YSCE SUBUNITPRE ...
P02213 PRS1, PRC1, PRE10 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT C1, PROTEINASE YSCE SUBUNIT 1,MU ...
P0A953 PRS2, PRC2, SCL1 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT C7- ALPHA, PROTEINASE YSCESUBUNI ...
P25043 PUP1 SACCHAROMYCES CEREVISIAE BAKER'S YEAST
MACROPAIN SUBUNIT PUP1, PROTEINASE YSCE SUBUNITPUP ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402