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GENERAL
TITLE
AP24534, A PAN-BCR-ABL INHIBITOR FOR CHRONIC MYELOID LEUKEMIA, POTENTLY INHIBITS THE T315I MUTANT AND OVERCOMES MUTATION-BASED RESISTANCE
DATE LAST MODIFIED
13 Oct 2021
RELEASE
3 Nov 2009
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
1.9
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1016/J.CCR.2009.09.028
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P00520 ABL1, ABL ESCHERICHIA COLI BL21(DE3) MOUSE
ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, ...
Mutations
P00520 ABL1, ABL ESCHERICHIA COLI BL21(DE3) MOUSE
ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1, ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402