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GENERAL
TITLE
IDENTIFICATION, SAR STUDIES AND X-RAY COCRYSTAL ANALYSIS OF A NOVEL FURANO-PYRIMIDINE AURORA KINASE A INHIBITOR
DATE LAST MODIFIED
1 Nov 2017
RELEASE
13 Oct 2010
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 61 2 2
RESOLUTION RANGE HIGH
2.35
RESOLUTION RANGE LOW
30
PUBMED ID
DOI
10.1002/CMDC.200900339
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
O14965 AURKA ESCHERICHIA COLI HUMAN AURORA KINASE A, AURORA-A, SERINE/THREONINE KINASE 15,AURORA/IPL1-RELATED KINASE 1, AURORA-RELATED KINASE 1, HARK1, BREASTTUMOR-AMPLIFIED KINASE HUMAN
AURORA KINASE A, AURORA-A, SERINE/THREONINE KINASE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402