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GENERAL
TITLE
DISCOVERY OF TETRAHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVE TAK-442: A POTENT, SELECTIVE AND ORALLY ACTIVE FACTOR XA INHIBITOR
DATE LAST MODIFIED
24 Apr 2013
RELEASE
1 Dec 2009
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.45
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/JM901699J

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O06976 F10 SPODOPTERA FRUGIPERDA HUMAN
STUART-PROWER FACTOR HEAVY CHAIN
P25144 F10 SPODOPTERA FRUGIPERDA HUMAN
STUART-PROWER FACTOR LIGHT CHAIN
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402