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GENERAL
TITLE
X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A POTENT 2H-ISOQUINOLIN-1-ONE INHIBITOR
DATE LAST MODIFIED
17 Jul 2019
RELEASE
8 Dec 2010
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
3
RESOLUTION RANGE LOW
44.45
PUBMED ID
DOI
10.1016/J.BMCL.2010.07.014
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q13464 ROCK1 SPODOPTERA FRUGIPERDA HUMAN RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1,P160 ROCK-1, P160ROCK, RENAL CARCINOMA ANTIGEN NY-REN-35 HUMAN
RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KIN ...
Mutations
Q13464 ROCK1 SPODOPTERA FRUGIPERDA HUMAN RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1,P160 ROCK-1, P160ROCK, RENAL CARCINOMA ANTIGEN NY-REN-35 HUMAN
RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KIN ...
Mutations
Q13464 ROCK1 SPODOPTERA FRUGIPERDA HUMAN RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1,P160 ROCK-1, P160ROCK, RENAL CARCINOMA ANTIGEN NY-REN-35 HUMAN
RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KIN ...
Mutations
Q13464 ROCK1 SPODOPTERA FRUGIPERDA HUMAN RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1,P160 ROCK-1, P160ROCK, RENAL CARCINOMA ANTIGEN NY-REN-35 HUMAN
RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402