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GENERAL
TITLE
IMIDAZO[1,2-A]PYRAZINE-BASED AURORA KINASE INHIBITORS
DATE LAST MODIFIED
22 Sept 2010
RELEASE
18 Aug 2010
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 61 2 2
RESOLUTION RANGE HIGH
3.05
RESOLUTION RANGE LOW
26
PUBMED ID
DOI
10.1016/J.BMCL.2010.07.008
PDBe
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LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
O14965 AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6 SPODOPTERA FRUGIPERDA HUMAN AURORA KINASE A, SERINE/THREONINE-PROTEIN KINASE AURORA-A,SERINE/THREONINE-PROTEIN KINASE 15, AURORA/IPL1-RELATED KINASE 1,AURORA-RELATED KINASE 1, ARK-1, HARK1, BREAST TUMOR-AMPLIFIED KINASE HUMAN
AURORA KINASE A, SERINE/THREONINE-PROTEIN KINASE A ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402