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GENERAL
TITLE
FURO[2,3-C]PYRIDINE-BASED INDANONE OXIMES AS POTENT AND SELECTIVE B- RAF INHIBITORS
DATE LAST MODIFIED
24 Jan 2018
RELEASE
19 Jan 2011
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 41 21 2
RESOLUTION RANGE HIGH
3.4
RESOLUTION RANGE LOW
30
PUBMED ID
DOI
10.1016/J.BMCL.2010.12.039
PDBe
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LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P15056 BRAF, BRAF1, RAFB1 SPODOPTERA FRUGIPERDA HUMAN P94, V-RAF MURINE SARCOMA VIRAL ONCOGENE HOMOLOG B1 HUMAN
P94, V-RAF MURINE SARCOMA VIRAL ONCOGENE HOMOLOG B ...
Mutations
P15056 BRAF, BRAF1, RAFB1 SPODOPTERA FRUGIPERDA HUMAN P94, V-RAF MURINE SARCOMA VIRAL ONCOGENE HOMOLOG B1 HUMAN
P94, V-RAF MURINE SARCOMA VIRAL ONCOGENE HOMOLOG B ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402