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GENERAL
TITLE
THE DISCOVERY OF POTENT, SELECTIVITY, AND ORALLY BIOAVAILABLE PYROZOLOQUINOLINES AS PDE10 INHIBITORS FOR THE TREATMENT OF SCHIZOPHRENIA
DATE LAST MODIFIED
-
RELEASE
25 Jan 2012
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.1
RESOLUTION RANGE LOW
30
PUBMED ID
DOI
10.1016/J.BMCL.2011.11.127

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q9Y233 PDE10A SPODOPTERA FRUGIPERDA HUMAN -- Mutations
Q9Y233 PDE10A SPODOPTERA FRUGIPERDA HUMAN -- Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402