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3D Structure View

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GENERAL
TITLE
DISCOVERY OF A SELECTIVE TRK INHIBITOR WITH EFFICACY IN RODENT CANCER TUMOR MODELS
DATE LAST MODIFIED
24 Jan 2018
RELEASE
8 Feb 2012
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 32
RESOLUTION RANGE HIGH
2.19
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ML200261D

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q16288 NTRK3, TRKC SPODOPTERA FRUGIPERDA HUMAN GP145-TRKC, TRK-C, NEUROTROPHIC TYROSINE KINASE RECEPTORTYPE 3, TRKC TYROSINE KINASE HUMAN
GP145-TRKC, TRK-C, NEUROTROPHIC TYROSINE KINASE RE ...
Mutations
Q16288 NTRK3, TRKC SPODOPTERA FRUGIPERDA HUMAN GP145-TRKC, TRK-C, NEUROTROPHIC TYROSINE KINASE RECEPTORTYPE 3, TRKC TYROSINE KINASE HUMAN
GP145-TRKC, TRK-C, NEUROTROPHIC TYROSINE KINASE RE ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402