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GENERAL
TITLE
HUMAN RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK 1) IN COMPLEX WITH INDAZOLE DERIVATIVE (COMPOUND 18)
DATE LAST MODIFIED
21 Mar 2012
RELEASE
8 Feb 2012
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 2 2 21
RESOLUTION RANGE HIGH
2.286
RESOLUTION RANGE LOW
20
PUBMED ID
DOI
10.1021/JM201289R
PDBe
3V8S
LIGANDS
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| Q13464 | ROCK1 | SPODOPTERA FRUGIPERDA | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE I, ROCK-I, P160 ROCK-1, P160ROCK | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, ... | Mutations | |
| Q13464 | ROCK1 | SPODOPTERA FRUGIPERDA | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE I, ROCK-I, P160 ROCK-1, P160ROCK | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, ... | Mutations | |
| Q13464 | ROCK1 | SPODOPTERA FRUGIPERDA | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE I, ROCK-I, P160 ROCK-1, P160ROCK | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, ... | Mutations | |
| Q13464 | ROCK1 | SPODOPTERA FRUGIPERDA | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE 1, RHO-ASSOCIATED, COILED-COIL-CONTAINING PROTEIN KINASE I, ROCK-I, P160 ROCK-1, P160ROCK | HUMAN | RENAL CARCINOMA ANTIGEN NY-REN-35, RHO-ASSOCIATED, ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402