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GENERAL
TITLE
CRYSTAL STRUCTURE OF HUMAN APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) WITH IMIDAZOPYRIDINE INHIBITOR
DATE LAST MODIFIED
20 Dec 2017
RELEASE
31 Oct 2012
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 65 2 2
RESOLUTION RANGE HIGH
2.4
RESOLUTION RANGE LOW
70.88
PUBMED ID
DOI
10.1016/J.BMCL.2012.10.084
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q99683 MAP3K5, ASK1, MAPKKK5, MEKK5 ESCHERICHIA COLI HUMAN APOPTOSIS SIGNAL-REGULATING KINASE 1, ASK-1, MAPK/ERK KINASEKINASE 5, MEK KINASE 5, MEKK 5 HUMAN
APOPTOSIS SIGNAL-REGULATING KINASE 1, ASK-1, MAPK/ ...
Mutations
Q99683 MAP3K5, ASK1, MAPKKK5, MEKK5 ESCHERICHIA COLI HUMAN APOPTOSIS SIGNAL-REGULATING KINASE 1, ASK-1, MAPK/ERK KINASEKINASE 5, MEK KINASE 5, MEKK 5 HUMAN
APOPTOSIS SIGNAL-REGULATING KINASE 1, ASK-1, MAPK/ ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402