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GENERAL
TITLE
EGFR KINASE DOMAIN T790M/L858R MUTANT WITH TAK-285
DATE LAST MODIFIED
25 Dec 2019
RELEASE
16 Jan 2013
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 2 3
RESOLUTION RANGE HIGH
2.35
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ML300327Z
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN KINASEERBB-1 HUMAN
PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402