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GENERAL
TITLE
CO-CRYSTAL STRUCTURE OF THE PPIASE DOMAIN OF FKBP51, RAPAMYCIN AND THE FRB FRAGMENT OF MTOR
DATE LAST MODIFIED
27 Mar 2013
RELEASE
6 Feb 2013
OBSOLETE
CLASSIFICATION
ISOMERASE/TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.45
RESOLUTION RANGE LOW
67.787
PUBMED ID
DOI
10.1128/MCB.00678-12
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q13451 AIG6, FKBP5, FKBP51 ESCHERICHIA COLI HUMAN PPIASE FKBP5, 51 KDA FK506-BINDING PROTEIN, 51 KDA FKBP,FKBP-51, 54 KDA PROGESTERONE RECEPTOR-ASSOCIATED IMMUNOPHILIN,ANDROGEN-REGULATED PROTEIN 6, FF1 ANTIGEN, FK506-BINDING PROTEIN 5,FKBP-5, FKBP54, P54, HSP90-BINDING IMMUNOPHILIN, ROTAMASE HUMAN
PPIASE FKBP5, 51 KDA FK506-BINDING PROTEIN, 51 KDA ...
Mutations
P42345 FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1 ESCHERICHIA COLI HUMAN FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATEDPROTEIN 1, FKBP12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN, MAMMALIANTARGET OF RAPAMYCIN, MTOR, MECHANISTIC TARGET OF RAPAMYCIN, RAPAMYCINAND FKBP12 TARGET 1, RAPAMYCIN TARGET PROTEIN 1 HUMAN
FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIA ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402