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GENERAL
TITLE
SMALL-MOLECULE LIGANDS BIND TO A DISTINCT POCKET IN RAS AND INHIBIT SOS-MEDIATED NUCLEOTIDE EXCHANGE ACTIVITY
DATE LAST MODIFIED
6 Jun 2012
RELEASE
4 Apr 2012
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
H 3
RESOLUTION RANGE HIGH
1.85
RESOLUTION RANGE LOW
30
PUBMED ID
DOI
10.1073/PNAS.1116510109
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P01116 KRAS, KRAS2, RASK2 ESCHERICHIA COLI HUMAN
KRAS 4B, K-RAS 2, KI-RAS, C-K-RAS, C-KI-RAS, GTPAS ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402