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GENERAL
TITLE
CRYSTAL STRUCTURE OF EGFR KINASE T790M IN COMPLEX WITH BIBW2992
DATE LAST MODIFIED
31 Oct 2012
RELEASE
29 Aug 2012
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
3.17
RESOLUTION RANGE LOW
82.48
PUBMED ID
DOI
10.1124/JPET.112.197756
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P00533 -- -- HUMAN PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN KINASEERBB-1 HUMAN
PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN ...
Mutations
P00533 -- -- HUMAN PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN KINASEERBB-1 HUMAN
PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402