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GENERAL
TITLE
STRUCTURAL BASIS AND SAR FOR OD 270, A LEAD STAGE 1,2,4-TRIAZOLE BASED SPECIFIC TANKYRASE1/2 INHIBITOR
DATE LAST MODIFIED
15 Nov 2017
RELEASE
20 Mar 2013
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 32 2 1
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
45
PUBMED ID
DOI
10.1021/JM4000566
PDBe
4HYF
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q9H2K2 | PARP5B, TANK2, TNKL, TNKS2 | ESCHERICHIA COLI | HUMAN | TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIK ... | Mutations | |
| Q9H2K2 | PARP5B, TANK2, TNKL, TNKS2 | ESCHERICHIA COLI | HUMAN | TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIK ... | Mutations | |
| Q9H2K2 | PARP5B, TANK2, TNKL, TNKS2 | ESCHERICHIA COLI | HUMAN | TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIK ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402