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3D Structure View

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GENERAL
TITLE
STRUCTURE OF THE MONOMERIC (V948R)GEFITINIB/ERLOTINIB RESISTANT DOUBLE MUTANT (L858R+T790M) EGFR KINASE DOMAIN CO-CRYSTALLIZED WITH GEFITINIB
DATE LAST MODIFIED
15 Nov 2017
RELEASE
16 Jan 2013
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 2 1
RESOLUTION RANGE HIGH
1.71
RESOLUTION RANGE LOW
42.64
PUBMED ID
DOI
10.1016/J.STR.2012.11.014

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN KINASEERBB-1 HUMAN
PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402