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GENERAL
TITLE
CO-CRYSTAL STRUCTURES OF THE LIPID KINASE PI3K ALPHA WITH PAN AND ISOFORM SELECTIVE INHIBITORS
DATE LAST MODIFIED
15 Nov 2017
RELEASE
2 Apr 2014
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2
RESOLUTION RANGE LOW
133.667
PUBMED ID
DOI
10.1016/J.BMCL.2013.05.007

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P42336 PIK3CA SPODOPTERA FRUGIPERDA HUMAN PI3-KINASE SUBUNIT ALPHA, PI3K-ALPHA, PI3KALPHA, PTDINS-3-KINASE SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE110 KDA CATALYTIC SUBUNIT ALPHA, PTDINS-3-KINASE SUBUNIT P110-ALPHA,P110ALPHA, PHOSPHOINOSITIDE-3-KINASE CATALYTIC ALPHA POLYPEPTIDE,SERINE/THREONINE PROTEIN KINASE PIK3CA HUMAN
PI3-KINASE SUBUNIT ALPHA, PI3K-ALPHA, PI3KALPHA, P ...
Mutations
P27986 GRB1, PIK3R1 SPODOPTERA FRUGIPERDA HUMAN PI3-KINASE REGULATORY SUBUNIT ALPHA, PI3K REGULATORY SUBUNITALPHA, PTDINS-3-KINASE REGULATORY SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL3-KINASE 85 KDA REGULATORY SUBUNIT ALPHA, PI3-KINASE SUBUNIT P85-ALPHA, PTDINS-3-KINASE REGULATORY SUBUNIT P85-ALPHA HUMAN
PI3-KINASE REGULATORY SUBUNIT ALPHA, PI3K REGULATO ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402