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GENERAL
TITLE
HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 5-{3-[3- METHOXY-5-(ISOQUIN-5-YL)PHENYL]PROP-1-YN-1-YL}6-ETHYLPRIMIDINE-2,4- DIAMINE
DATE LAST MODIFIED
17 Dec 2014
RELEASE
9 Oct 2013
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 2 2 21
RESOLUTION RANGE HIGH
1.76
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/BI400852H

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P00374 DHFR, HUDHFR ESCHERICHIA COLI HUMAN -- HUMAN -- Mutations
P00374 DHFR, HUDHFR ESCHERICHIA COLI HUMAN -- HUMAN -- Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402