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GENERAL
TITLE
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE COMPLEX WITH BMS-791325 ALSO KNOWN AS (1AR,12BS)-8- CYCLOHEXYL-N-(DIMETHYLSULFAMOYL)-11-METHOXY-1A-{[(1R,5S)-3-METHYL-3, 8-DIAZABICYCLO[3.2.1]OCT-8-YL]CARBONYL}-1,1A,2,12B- TETRAHYDROCYCLOPROPA[D]INDOLO[2,1-A][2]BENZAZEPINE-5-CARBOXAMIDE AND 2-(4-FLUOROPHENYL)-N-METHYL-6-[(METHYLSULFONYL)AMINO]-5-(PROPAN-2- YLOXY)-1-BENZOFURAN-3-CARBOXAMIDE
DATE LAST MODIFIED
29 Jul 2020
RELEASE
19 Mar 2014
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 2 2 2
RESOLUTION RANGE HIGH
2.75
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/JM4016894

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q9WMX2 NS5B ESCHERICHIA COLI HCV
NS5B, P68
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402