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GENERAL
TITLE
CRYSTAL STRUCTURE OF THE HUMAN PXR-LBD IN COMPLEX WITH N-{(2R)-1- [(4S)-4-(4-CHLOROPHENYL)-4-HYDROXY-3,3-DIMETHYLPIPERIDIN-1-YL]-3- METHYL-1-OXOBUTAN-2-YL}-3-HYDROXY-3-METHYLBUTANAMIDE
DATE LAST MODIFIED
22 Nov 2017
RELEASE
27 Aug 2014
OBSOLETE
CLASSIFICATION
TRANSCRIPTION/TRANSCRIPTION INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 43 21 2
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/JM5003167
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O75469 NR1I2, PXR ESCHERICHIA COLI HUMAN
ORPHAN NUCLEAR RECEPTOR PAR1, ORPHAN NUCLEAR RECEP ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402