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GENERAL
TITLE
IDENTIFICATION OF NOVEL HSP90/ISOFORM SELECTIVE INHIBITORS USING STRUCTURE-BASED DRUG DESIGN. DEMONSTRATION OF POTENTIAL UTILITY IN TREATING CNS DISORDERS SUCH AS HUNTINGTON'S DISEASE
DATE LAST MODIFIED
22 Nov 2017
RELEASE
9 Apr 2014
OBSOLETE
CLASSIFICATION
CHAPERONE/CHAPERONE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 2 2 2
RESOLUTION RANGE HIGH
1.86
RESOLUTION RANGE LOW
56.31
PUBMED ID
DOI
10.1021/JM500042S
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P07900 HSP90AA1, HSP90A, HSPC1, HSPCA SPODOPTERA FRUGIPERDA HUMAN
HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402