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GENERAL
TITLE
THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR
DATE LAST MODIFIED
22 Nov 2017
RELEASE
24 Feb 2016
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
3.25
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1158/1535-7163.MCT-15-0262
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P15056 BRAF, BRAF1, RAFB1 ESCHERICHIA COLI BL21(DE3) HUMAN
PROTO-ONCOGENE B-RAF, P94, V-RAF MURINE SARCOMA VI ...
Mutations
P15056 BRAF, BRAF1, RAFB1 ESCHERICHIA COLI BL21(DE3) HUMAN
PROTO-ONCOGENE B-RAF, P94, V-RAF MURINE SARCOMA VI ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402