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GENERAL
TITLE
CRYSTAL STRUCTURE OF FMS KINASE DOMAIN WITH A SMALL MOLECULAR INHIBITOR, PLX3397
DATE LAST MODIFIED
-
RELEASE
12 Aug 2015
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 43 21 2
RESOLUTION RANGE HIGH
2.8
RESOLUTION RANGE LOW
60.471
PUBMED ID
DOI
10.1056/NEJMOA1411366
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P07333 CSF1R, FMS SPODOPTERA FRUGIPERDA HUMAN CSF-1 RECEPTOR, CSF-1-R, CSF-1R, M-CSF-R, PROTO-ONCOGENE C-FMS HUMAN
CSF-1 RECEPTOR, CSF-1-R, CSF-1R, M-CSF-R, PROTO-ON ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402