4RFZ logo

4RFZ

3D Structure View

Loading...

More Info

GENERAL
TITLE
CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 6- (DIMETHYLAMINO)-8-FLUORO-2-[2-(HYDROXYMETHYL)-3-[1-METHYL-5-[[5- (MORPHOLINE-4-CARBONYL)-2-PYRIDYL]AMINO]-6-OXO-3- PYRIDYL]PHENYL]ISOQUINOLIN-1-ONE
DATE LAST MODIFIED
17 Jul 2019
RELEASE
24 Dec 2014
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 2
RESOLUTION RANGE HIGH
1.17
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1016/J.BMCL.2014.11.030
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q06187 BTK, AGMX1, ATK, BPK SPODOPTERA FRUGIPERDA HUMAN
AGAMMAGLOBULINEMIA TYROSINE KINASE, ATK, B-CELL PR ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402