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GENERAL
TITLE
CRYSTAL STRUCTURE OF BTK KINASE DOMAIN COMPLEXED WITH 2-[8-FLUORO-2- [2-(HYDROXYMETHYL)-3-[1-METHYL-5-[[5-(4-METHYLPIPERAZIN-1-YL)-2- PYRIDYL]AMINO]-6-OXO-3-PYRIDYL]PHENYL]-1-OXO-3,4-DIHYDROISOQUINOLIN- 6-YL]-2-METHYL-PROPANENITRILE
DATE LAST MODIFIED
17 Jul 2019
RELEASE
24 Dec 2014
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 2
RESOLUTION RANGE HIGH
2.5
RESOLUTION RANGE LOW
42.76
PUBMED ID
DOI
10.1016/J.BMCL.2014.11.030
PDBe
4RG0
LIGANDS
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q8IYM1 | BTK, AGMX1, ATK, BPK | SPODOPTERA FRUGIPERDA | HUMAN | AGAMMAGLOBULINEMIA TYROSINE KINASE, ATK, B-CELL PR ... |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402