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GENERAL
TITLE
THE CRYSTAL STRUCTURE OF HUMAN ABL1 T315I GATEKEEPER MUTANT KINASE DOMAIN IN COMPLEX WITH AXITINIB
DATE LAST MODIFIED
22 Nov 2017
RELEASE
11 Feb 2015
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 2 21 21
RESOLUTION RANGE HIGH
2.4
RESOLUTION RANGE LOW
85.957
PUBMED ID
DOI
10.1038/NATURE14119

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P00519 ABL1, ABL, JTK7 SPODOPTERA FRUGIPERDA HUMAN
ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1,A ...
Mutations
P00519 ABL1, ABL, JTK7 SPODOPTERA FRUGIPERDA HUMAN
ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1,A ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402