4WAF logo

4WAF

3D Structure View

Loading...

More Info

GENERAL
TITLE
CRYSTAL STRUCTURE OF A NOVEL TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE IN AN ENGINEERED PI3K ALPHA
DATE LAST MODIFIED
28 Jan 2015
RELEASE
31 Dec 2014
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.389
RESOLUTION RANGE LOW
48.65
PUBMED ID
DOI
10.1021/ML500353P
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P29317 PIK3CA TRICHOPLUSIA NI HUMAN
PTDINS-3-KINASE SUBUNIT ALPHA,PHOSPHATIDYLINOSITOL ...
P27986 PIK3R1, GRB1 TRICHOPLUSIA NI HUMAN
PTDINS-3-KINASE REGULATORY SUBUNIT ALPHA,PHOSPHATI ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402