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GENERAL
TITLE
DISCOVERY OF BENZOTRIAZOLO DIAZEPINES AS ORALLY-ACTIVE INHIBITORS OF BET BROMODOMAINS: CRYSTAL STRUCTURE OF BRD4 WITH CPI-13
DATE LAST MODIFIED
30 Mar 2016
RELEASE
11 Nov 2015
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.2
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ML500411H
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O60885 BRD4, HUNK1 ESCHERICHIA COLI HUMAN
PROTEIN HUNK1
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402