4X2I

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 4X2I_A

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GENERAL

TITLE

DISCOVERY OF BENZOTRIAZOLO DIAZEPINES AS ORALLY-ACTIVE INHIBITORS OF BET BROMODOMAINS: CRYSTAL STRUCTURE OF BRD4 WITH CPI-13

DATE LAST MODIFIED

30 Mar 2016

RELEASE

11 Nov 2015

OBSOLETE

CLASSIFICATION

SIGNALING PROTEIN

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 21 21 21

RESOLUTION RANGE HIGH

1.2

RESOLUTION RANGE LOW

PUBMED ID

DOI

10.1021/ML500411H

PDBe

LIGANDS

Structure Chain	Target Protein	Gene	Expression System	Organism	Synonims	Actions
	Q9NX46	BRD4, HUNK1	ESCHERICHIA COLI	HUMAN	PROTEIN HUNK1

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402