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GENERAL
TITLE
CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2886721
DATE LAST MODIFIED
22 Nov 2017
RELEASE
24 Dec 2014
OBSOLETE
CLASSIFICATION
HYDROLASE/HYDROLASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.77
RESOLUTION RANGE LOW
130
PUBMED ID
DOI
10.1523/JNEUROSCI.4129-14.2015
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P56817 BACE1, BACE, KIAA1149 ESCHERICHIA COLI HUMAN
ASPARTYL PROTEASE 2,ASP 2,BETA-SITE AMYLOID PRECUR ...
Mutations
P56817 BACE1, BACE, KIAA1149 ESCHERICHIA COLI HUMAN
ASPARTYL PROTEASE 2,ASP 2,BETA-SITE AMYLOID PRECUR ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402