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GENERAL
TITLE
CO-CRYSTAL STRUCTURE OF PERK BOUND TO 1-[5-(4-AMINO-2,7-DIMETHYL-7H- PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-FLUORO- 5-(TRIFLUOROMETHYL)PHENYL]ETHANONE INHIBITOR
DATE LAST MODIFIED
25 Feb 2015
RELEASE
28 Jan 2015
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 32 2 1
RESOLUTION RANGE HIGH
2.65
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/JM5017494
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q9NZJ5 EIF2AK3, PEK, PERK ESCHERICHIA COLI HUMAN
PRKR-LIKE ENDOPLASMIC RETICULUM KINASE,PANCREATIC ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402