4Z16

3D Structure View

CAVITIES

STRUCTURE SETTINGS

LIGANDS

Chain 4Z16_A

Chain 4Z16_B

Chain 4Z16_C

Chain 4Z16_D

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GENERAL

TITLE

CRYSTAL STRUCTURE OF THE JAK3 KINASE DOMAIN COVALENTLY BOUND TO N-(3- (((5-CHLORO-2-((2-METHOXY-4-(4-METHYLPIPERAZIN-1-YL)PHENYL)AMINO) PYRIMIDIN-4-YL)AMINO)METHYL)PHENYL)ACRYLAMIDE

DATE LAST MODIFIED

RELEASE

10 Feb 2016

OBSOLETE

CLASSIFICATION

TRANSFERASE/TRANSFERASE INHIBITOR

EXPERIMENT TYPE

X-RAY DIFFRACTION

SPACE GROUP

P 1

RESOLUTION RANGE HIGH

2.9

RESOLUTION RANGE LOW

92.91

PUBMED ID

26258521

DOI

10.1021/ACS.JMEDCHEM.5B00710

PDBe

4Z16

LIGANDS

756325 , 1041888

Chains

Target Protein	Gene	Expression System	Organism	Synonims
P02070	JAK3	TRICHOPLUSIA NI	HUMAN	JANUS KINASE 3,JAK-3,LEUKOCYTE JANUS KINASE,L-JAK
P0DTC2	JAK3	TRICHOPLUSIA NI	HUMAN	JANUS KINASE 3,JAK-3,LEUKOCYTE JANUS KINASE,L-JAK
P02070	JAK3	TRICHOPLUSIA NI	HUMAN	JANUS KINASE 3,JAK-3,LEUKOCYTE JANUS KINASE,L-JAK
P0DTC2	JAK3	TRICHOPLUSIA NI	HUMAN	JANUS KINASE 3,JAK-3,LEUKOCYTE JANUS KINASE,L-JAK

NGL Viewer is used for the molecular visualization.

AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402