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GENERAL
TITLE
STRUCTURE ENABLED DISCOVERY OF A STAPLED PEPTIDE INHIBITOR TO TARGET THE ONCOGENIC TRANSCRIPTIONAL REPRESSOR TLE1
DATE LAST MODIFIED
16 Oct 2019
RELEASE
5 Apr 2017
OBSOLETE
CLASSIFICATION
TRANSCRIPTION
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.04
RESOLUTION RANGE LOW
57
PUBMED ID
DOI
10.1002/CHEM.201700747
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q04724 TLE1 SPODOPTERA FRUGIPERDA HUMAN E(SP1) HOMOLOG,ENHANCER OF SPLIT GROUCHO-LIKE PROTEIN 1,ESG1 HUMAN
E(SP1) HOMOLOG,ENHANCER OF SPLIT GROUCHO-LIKE PROT ...
Mutations
Q04724 TLE1 SPODOPTERA FRUGIPERDA HUMAN E(SP1) HOMOLOG,ENHANCER OF SPLIT GROUCHO-LIKE PROTEIN 1,ESG1 HUMAN
E(SP1) HOMOLOG,ENHANCER OF SPLIT GROUCHO-LIKE PROT ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402