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GENERAL
TITLE
COMBINATORIAL ENGINEERING OF PROTEOLYTICALLY RESISTANT APPI VARIANTS THAT SELECTIVELY INHIBIT HUMAN KALLIKREIN 6 FOR CANCER THERAPY
DATE LAST MODIFIED
12 Jun 2019
RELEASE
30 May 2018
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.296
RESOLUTION RANGE LOW
48.97
PUBMED ID
DOI
10.1074/JBC.RA117.000871
PDBe
5NX3
LIGANDS
--
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| Q92876 | KLK6, PRSS18, PRSS9 | TRICHOPLUSIA NI | HUMAN | NEUROSIN,PROTEASE M,SP59,SERINE PROTEASE 18,SERINE ... | Mutations | |
| P05067 | APP, A4, AD1 | KOMAGATAELLA PHAFFII GS115 | HUMAN | ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ... | Mutations | |
| P05067 | APP, A4, AD1 | KOMAGATAELLA PHAFFII GS115 | HUMAN | ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ... | Mutations | |
| P05067 | APP, A4, AD1 | KOMAGATAELLA PHAFFII GS115 | HUMAN | ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402