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GENERAL
TITLE
COMBINATORIAL ENGINEERING OF PROTEOLYTICALLY RESISTANT APPI VARIANTS THAT SELECTIVELY INHIBIT HUMAN KALLIKREIN 6 FOR CANCER THERAPY
DATE LAST MODIFIED
12 Jun 2019
RELEASE
30 May 2018
OBSOLETE
CLASSIFICATION
HYDROLASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.296
RESOLUTION RANGE LOW
48.97
PUBMED ID
DOI
10.1074/JBC.RA117.000871
LIGANDS
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q92876 KLK6, PRSS18, PRSS9 TRICHOPLUSIA NI HUMAN
NEUROSIN,PROTEASE M,SP59,SERINE PROTEASE 18,SERINE ...
Mutations
P05067 APP, A4, AD1 KOMAGATAELLA PHAFFII GS115 HUMAN
ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ...
Mutations
P05067 APP, A4, AD1 KOMAGATAELLA PHAFFII GS115 HUMAN
ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ...
Mutations
P05067 APP, A4, AD1 KOMAGATAELLA PHAFFII GS115 HUMAN
ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402