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GENERAL
TITLE
STRUCTURE OF A CHIMAERIC BETA3-ALPHA5 GABAA RECEPTOR IN COMPLEX WITH NANOBODY NB25 AND PREGNANOLONE
DATE LAST MODIFIED
29 Jul 2020
RELEASE
1 Nov 2017
OBSOLETE
CLASSIFICATION
MEMBRANE PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 2 3
RESOLUTION RANGE HIGH
3.19
RESOLUTION RANGE LOW
205.13
PUBMED ID
DOI
10.1038/NSMB.3484
PDBe
5O8F
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| P28472 | GABRB3, GABRA5 | HOMO SAPIENS | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR SUBUNITALPHA-5,GABA(A) RECEPTOR SUBUNIT ALPHA-5EXTRACELLULAR REGION OF HUMAN GBRB3 (MATURE POLYPEPTIDE RESIDUES 1-217 FROM UNIPROT P28472), THE TRANSMEMBRANE REGION FROM HUMAN GBRA5(MATURE POLYPEPTIDE RESIDUES 226-431 FROM UNIPROT P31644 WITH THEEXCEPTION OF THE M3-M4 LOOP, RESIDUES 316-392, WHICH WERE SUBSTITUTEDBY SQPARAA) AND A C-TERMINAL RHO-1D4 PURIFICATION TAG (TETSQVAPA). | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR S ... | Mutations | |
| P28472 | GABRB3, GABRA5 | HOMO SAPIENS | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR SUBUNITALPHA-5,GABA(A) RECEPTOR SUBUNIT ALPHA-5EXTRACELLULAR REGION OF HUMAN GBRB3 (MATURE POLYPEPTIDE RESIDUES 1-217 FROM UNIPROT P28472), THE TRANSMEMBRANE REGION FROM HUMAN GBRA5(MATURE POLYPEPTIDE RESIDUES 226-431 FROM UNIPROT P31644 WITH THEEXCEPTION OF THE M3-M4 LOOP, RESIDUES 316-392, WHICH WERE SUBSTITUTEDBY SQPARAA) AND A C-TERMINAL RHO-1D4 PURIFICATION TAG (TETSQVAPA). | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR S ... | Mutations | |
| P28472 | GABRB3, GABRA5 | HOMO SAPIENS | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR SUBUNITALPHA-5,GABA(A) RECEPTOR SUBUNIT ALPHA-5EXTRACELLULAR REGION OF HUMAN GBRB3 (MATURE POLYPEPTIDE RESIDUES 1-217 FROM UNIPROT P28472), THE TRANSMEMBRANE REGION FROM HUMAN GBRA5(MATURE POLYPEPTIDE RESIDUES 226-431 FROM UNIPROT P31644 WITH THEEXCEPTION OF THE M3-M4 LOOP, RESIDUES 316-392, WHICH WERE SUBSTITUTEDBY SQPARAA) AND A C-TERMINAL RHO-1D4 PURIFICATION TAG (TETSQVAPA). | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR S ... | Mutations | |
| P28472 | GABRB3, GABRA5 | HOMO SAPIENS | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR SUBUNITALPHA-5,GABA(A) RECEPTOR SUBUNIT ALPHA-5EXTRACELLULAR REGION OF HUMAN GBRB3 (MATURE POLYPEPTIDE RESIDUES 1-217 FROM UNIPROT P28472), THE TRANSMEMBRANE REGION FROM HUMAN GBRA5(MATURE POLYPEPTIDE RESIDUES 226-431 FROM UNIPROT P31644 WITH THEEXCEPTION OF THE M3-M4 LOOP, RESIDUES 316-392, WHICH WERE SUBSTITUTEDBY SQPARAA) AND A C-TERMINAL RHO-1D4 PURIFICATION TAG (TETSQVAPA). | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR S ... | Mutations | |
| P28472 | GABRB3, GABRA5 | HOMO SAPIENS | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR SUBUNITALPHA-5,GABA(A) RECEPTOR SUBUNIT ALPHA-5EXTRACELLULAR REGION OF HUMAN GBRB3 (MATURE POLYPEPTIDE RESIDUES 1-217 FROM UNIPROT P28472), THE TRANSMEMBRANE REGION FROM HUMAN GBRA5(MATURE POLYPEPTIDE RESIDUES 226-431 FROM UNIPROT P31644 WITH THEEXCEPTION OF THE M3-M4 LOOP, RESIDUES 316-392, WHICH WERE SUBSTITUTEDBY SQPARAA) AND A C-TERMINAL RHO-1D4 PURIFICATION TAG (TETSQVAPA). | HUMAN | GABA(A) RECEPTOR SUBUNIT BETA-3,GABA(A) RECEPTOR S ... | Mutations | |
| -- | ESCHERICHIA COLI | LLAMA | -- | LLAMA | -- | |||
| -- | ESCHERICHIA COLI | LLAMA | -- | LLAMA | -- | |||
| -- | ESCHERICHIA COLI | LLAMA | -- | LLAMA | -- | |||
| -- | ESCHERICHIA COLI | LLAMA | -- | LLAMA | -- | |||
| -- | ESCHERICHIA COLI | LLAMA | -- | LLAMA | -- |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402