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GENERAL
TITLE
THE CRYO-EM STRUCTURE OF HUMAN TFIIH
DATE LAST MODIFIED
30 Mar 2022
RELEASE
13 Sept 2017
OBSOLETE
CLASSIFICATION
TRANSCRIPTION
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
4.4
RESOLUTION RANGE LOW
4.4
PUBMED ID
DOI
10.1038/NATURE23903
PDBe
--
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P19447 -- -- HUMAN BASIC TRANSCRIPTION FACTOR 2 89 KDA SUBUNIT,BTF2 P89,DNAEXCISION REPAIR PROTEIN ERCC-3,DNA REPAIR PROTEIN COMPLEMENTING XP-BCELLS,TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX 89 KDA SUBUNIT,TFIIHP89,XERODERMA PIGMENTOSUM GROUP B-COMPLEMENTING PROTEIN,BASICTRANSCRIPTION FACTOR 2 89 KDA SUBUNIT,BTF2 P89,DNA EXCISION REPAIRPROTEIN ERCC-3,DNA REPAIR PROTEIN COMPLEMENTING XP-B CELLS,TFIIHBASAL TRANSCRIPTION FACTOR COMPLEX 89 KDA SUBUNIT,TFIIH P89,XERODERMAPIGMENTOSUM GROUP B-COMPLEMENTING PROTEIN HUMAN
BASIC TRANSCRIPTION FACTOR 2 89 KDA SUBUNIT,BTF2 P ...
Mutations
P18074 -- -- HUMAN BASIC TRANSCRIPTION FACTOR 2 80 KDA SUBUNIT,BTF2 P80,CXPD,DNA EXCISION REPAIR PROTEIN ERCC-2,DNA REPAIR PROTEIN COMPLEMENTINGXP-D CELLS,TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX 80 KDA SUBUNIT,TFIIH P80,XERODERMA PIGMENTOSUM GROUP D-COMPLEMENTING PROTEIN HUMAN
BASIC TRANSCRIPTION FACTOR 2 80 KDA SUBUNIT,BTF2 P ...
Mutations
Q92759 -- -- HUMAN BASIC TRANSCRIPTION FACTOR 2 52 KDA SUBUNIT,BTF2 P52,GENERALTRANSCRIPTION FACTOR IIH POLYPEPTIDE 4,TFIIH BASAL TRANSCRIPTIONFACTOR COMPLEX P52 SUBUNIT,BASIC TRANSCRIPTION FACTOR 2 52 KDASUBUNIT,BTF2 P52,GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 4,TFIIHBASAL TRANSCRIPTION FACTOR COMPLEX P52 SUBUNIT HUMAN
BASIC TRANSCRIPTION FACTOR 2 52 KDA SUBUNIT,BTF2 P ...
Mutations
Q13888 -- -- HUMAN BASIC TRANSCRIPTION FACTOR 2 44 KDA SUBUNIT,BTF2 P44,GENERALTRANSCRIPTION FACTOR IIH POLYPEPTIDE 2,TFIIH BASAL TRANSCRIPTIONFACTOR COMPLEX P44 SUBUNIT HUMAN
BASIC TRANSCRIPTION FACTOR 2 44 KDA SUBUNIT,BTF2 P ...
Mutations
Q13889 -- -- HUMAN BASIC TRANSCRIPTION FACTOR 2 34 KDA SUBUNIT,BTF2 P34,GENERALTRANSCRIPTION FACTOR IIH POLYPEPTIDE 3,TFIIH BASAL TRANSCRIPTIONFACTOR COMPLEX P34 SUBUNIT HUMAN
BASIC TRANSCRIPTION FACTOR 2 34 KDA SUBUNIT,BTF2 P ...
Mutations
Q6ZYL4 -- -- HUMAN GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 5,TFB5ORTHOLOG,TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX TTD-A SUBUNIT HUMAN
GENERAL TRANSCRIPTION FACTOR IIH POLYPEPTIDE 5,TFB ...
Mutations
-- -- HOMO SAPIENS -- HOMO SAPIENS --
-- -- HOMO SAPIENS -- HOMO SAPIENS --
-- -- HOMO SAPIENS -- HOMO SAPIENS --
-- -- HOMO SAPIENS -- HOMO SAPIENS --
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402