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GENERAL
TITLE
CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF NECITUMUMAB (FAB11F8) IN COMPLEX WITH DOMAIN III FROM A CETUXIMAB RESISTANT VARIANT OF EGFR (SEGFRD3-S468R)
DATE LAST MODIFIED
29 Jul 2020
RELEASE
6 Dec 2017
OBSOLETE
CLASSIFICATION
TRANSFERASE/IMMUNE SYSTEM
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 2 1
RESOLUTION RANGE HIGH
2.795
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1158/1535-7163.MCT-17-0575

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN
PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ...
Mutations
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN
PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ...
Mutations
P0DP06 -- MUS MUSCULUS HUMAN --
A0A0A0MRZ8 -- MUS MUSCULUS HUMAN --
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN
PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ...
Mutations
P0DP06 -- MUS MUSCULUS HUMAN --
A0A0A0MRZ8 -- MUS MUSCULUS HUMAN --
P0DP06 -- MUS MUSCULUS HUMAN --
P00533 EGFR, ERBB, ERBB1, HER1 SPODOPTERA FRUGIPERDA HUMAN
PROTO-ONCOGENE C-ERBB-1,RECEPTOR TYROSINE-PROTEIN ...
Mutations
P0DP06 -- MUS MUSCULUS HUMAN --
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402