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GENERAL
TITLE
CRYSTAL STRUCTURE OF MUTANT HUMAN GERANYLGERANYL PYROPHOSPHATE SYNTHASE (Y246D) IN COMPLEX WITH BISPHOSPHONATE INHIBITOR FV0109
DATE LAST MODIFIED
-
RELEASE
5 Sept 2018
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 4 2 2
RESOLUTION RANGE HIGH
3.5
RESOLUTION RANGE LOW
97.24
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00886
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O95749 GGPS1 ESCHERICHIA COLI HUMAN
GGPPSASE,(2E,6E)-FARNESYL DIPHOSPHATE SYNTHASE,DIM ...
Mutations
O95749 GGPS1 ESCHERICHIA COLI HUMAN
GGPPSASE,(2E,6E)-FARNESYL DIPHOSPHATE SYNTHASE,DIM ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402