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3D Structure View

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GENERAL
TITLE
STRUCTURE OF CDK12/CYCK IN COMPLEX WITH A SMALL MOLECULE INHIBITOR N- (4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-N-((1R,4R)-4-(QUINAZOLIN-2- YLAMINO)CYCLOHEXYL)ACETAMIDE
DATE LAST MODIFIED
26 Sept 2018
RELEASE
29 Aug 2018
OBSOLETE
CLASSIFICATION
TRANSFERASE/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.75
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00683

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q9NYV4 CDK12, CRK7, CRKRS, KIAA0904 UNIDENTIFIED BACULOVIRUS HUMAN
CDC2-RELATED KINASE,ARGININE/SERINE-RICH,CRKRS,CEL ...
Mutations
O75909 CCNK, CPR4 UNIDENTIFIED BACULOVIRUS HUMAN -- Mutations
Q9NYV4 CDK12, CRK7, CRKRS, KIAA0904 UNIDENTIFIED BACULOVIRUS HUMAN
CDC2-RELATED KINASE,ARGININE/SERINE-RICH,CRKRS,CEL ...
Mutations
O75909 CCNK, CPR4 UNIDENTIFIED BACULOVIRUS HUMAN -- Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402