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GENERAL
TITLE
HALK IN COMPLEX WITH COMPOUND 9 (6-(((1S)-1-(5-FLUOROPYRIDIN-2-YL) ETHYL)AMINO)-1-(3-METHYL-1H-PYRAZOL-5-YL)-1H-PYRROLO[2,3-B]PYRIDIN-3- YL)(MORPHOLIN-4-YL)METHANONE
DATE LAST MODIFIED
5 Jun 2019
RELEASE
1 May 2019
OBSOLETE
CLASSIFICATION
TRANSFERASE/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.455
RESOLUTION RANGE LOW
38.43
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B01630
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q9UM73 ALK UNIDENTIFIED BACULOVIRUS HUMAN ANAPLASTIC LYMPHOMA KINASE HUMAN
ANAPLASTIC LYMPHOMA KINASE
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402