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GENERAL
TITLE
RAS GUANINE EXCHANGE FACTOR SOS1 (REM-CDC25) IN COMPLEX WITH KRAS(G12C) AND FRAGMENT SCREENING HIT F4
DATE LAST MODIFIED
14 Aug 2019
RELEASE
6 Feb 2019
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 4 2 2
RESOLUTION RANGE HIGH
2.4
RESOLUTION RANGE LOW
47.43
PUBMED ID
DOI
10.1073/PNAS.1812963116
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P01116 KRAS, KRAS2, RASK2 ESCHERICHIA COLI HUMAN K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS HUMAN
K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS
Mutations
Q07889 SOS1 ESCHERICHIA COLI HUMAN SOS-1 HUMAN
SOS-1
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402