6F78 logo

6F78

3D Structure View

Loading...

More Info

GENERAL
TITLE
POTENT AND SELECTIVE ALDO-KETO REDUCTASE 1C3 (AKR1C3) INHIBITORS BASED ON THE BENZOISOXAZOLE MOIETY: APPLICATION OF A BIOISOSTERIC SCAFFOLD HOPPING APPROACH TO FLUFENAMIC ACID
DATE LAST MODIFIED
11 Apr 2018
RELEASE
4 Apr 2018
OBSOLETE
CLASSIFICATION
OXIDOREDUCTASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
1.3
RESOLUTION RANGE LOW
80.11
PUBMED ID
DOI
10.1016/J.EJMECH.2018.03.040

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P42330 AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ESCHERICHIA COLI HUMAN 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5,17-BETA-HSD 5,3-ALPHA-HSD TYPE II,BRAIN,3-ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 2,3-ALPHA-HSD TYPE 2,CHLORDECONE REDUCTASE HOMOLOG HAKRB,DIHYDRODIOLDEHYDROGENASE 3,DD3,DIHYDRODIOL DEHYDROGENASE TYPE I,HA1753,INDANOLDEHYDROGENASE,PROSTAGLANDIN F SYNTHASE,PGFS,TESTOSTERONE 17-BETA-DEHYDROGENASE 5,TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE1.3.1.20 HUMAN
17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5,17-BET ...
Mutations
P42330 AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ESCHERICHIA COLI HUMAN 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5,17-BETA-HSD 5,3-ALPHA-HSD TYPE II,BRAIN,3-ALPHA-HYDROXYSTEROID DEHYDROGENASE TYPE 2,3-ALPHA-HSD TYPE 2,CHLORDECONE REDUCTASE HOMOLOG HAKRB,DIHYDRODIOLDEHYDROGENASE 3,DD3,DIHYDRODIOL DEHYDROGENASE TYPE I,HA1753,INDANOLDEHYDROGENASE,PROSTAGLANDIN F SYNTHASE,PGFS,TESTOSTERONE 17-BETA-DEHYDROGENASE 5,TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE1.3.1.20 HUMAN
17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 5,17-BET ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402