6FER logo

6FER

3D Structure View

Loading...

More Info

GENERAL
TITLE
CRYSTAL STRUCTURE OF HUMAN DDR2 KINASE IN COMPLEX WITH 2-[4,5- DIFLUORO-2-OXO-1'-(1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBONYL) SPIRO[INDOLE-3,4'-PIPERIDINE]-1-YL]-N-(2,2,2-TRIFLUOROETHYL)ACETAMIDE
DATE LAST MODIFIED
27 Mar 2019
RELEASE
28 Nov 2018
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2.87
RESOLUTION RANGE LOW
177.99
PUBMED ID
DOI
10.1021/ACSCHEMBIO.8B00866
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
Q16832 DDR2, NTRKR3, TKT, TYRO10 SPODOPTERA FRUGIPERDA HUMAN DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAMILY MEMBERB,DISCOIDIN DOMAIN-CONTAINING RECEPTOR TYROSINE KINASE 2,NEUROTROPHICTYROSINE KINASE,RECEPTOR-RELATED 3,RECEPTOR PROTEIN-TYROSINE KINASETKT,TYROSINE-PROTEIN KINASE TYRO10 HUMAN
DISCOIDIN DOMAIN RECEPTOR 2,CD167 ANTIGEN-LIKE FAM ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402