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GENERAL
TITLE
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR, AZD3229
DATE LAST MODIFIED
31 Oct 2018
RELEASE
19 Sept 2018
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
2
RESOLUTION RANGE LOW
45.09
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B00938

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P10721 KIT, SCFR ESCHERICHIA COLI BL21(DE3) HUMAN SCFR,PIEBALD TRAIT PROTEIN,PBT,PROTO-ONCOGENE C-KIT,TYROSINE-PROTEIN KINASE KIT,P145 C-KIT,V-KIT HARDY-ZUCKERMAN 4 FELINESARCOMA VIRAL ONCOGENE HOMOLOGMUTATIONS TO OPTIMISE PROTEIN EXPRESSION (I563S, V569S, Y609Q, L631S,M651E, I662H, D768H, R804N, V825D, C844S, L890S, H894Y, L912D,L923D), AND THE KINASE INSERT DOMAIN(S688-D765) DELETED AND REPLACEDWITH THE SEQUENCE EFVPYKVAPEDLYKDFLT HUMAN
SCFR,PIEBALD TRAIT PROTEIN,PBT,PROTO-ONCOGENE C-KI ...
Mutations
P10721 KIT, SCFR ESCHERICHIA COLI BL21(DE3) HUMAN SCFR,PIEBALD TRAIT PROTEIN,PBT,PROTO-ONCOGENE C-KIT,TYROSINE-PROTEIN KINASE KIT,P145 C-KIT,V-KIT HARDY-ZUCKERMAN 4 FELINESARCOMA VIRAL ONCOGENE HOMOLOGMUTATIONS TO OPTIMISE PROTEIN EXPRESSION (I563S, V569S, Y609Q, L631S,M651E, I662H, D768H, R804N, V825D, C844S, L890S, H894Y, L912D,L923D), AND THE KINASE INSERT DOMAIN(S688-D765) DELETED AND REPLACEDWITH THE SEQUENCE EFVPYKVAPEDLYKDFLT HUMAN
SCFR,PIEBALD TRAIT PROTEIN,PBT,PROTO-ONCOGENE C-KI ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402