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GENERAL
TITLE
CRYSTAL STRUCTURE OF THE ACVR1 (ALK2) KINASE IN COMPLEX WITH FKBP12 AND THE INHIBITOR E6201
DATE LAST MODIFIED
25 Mar 2020
RELEASE
11 Sept 2019
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.52
RESOLUTION RANGE LOW
41.32
PUBMED ID
DOI
10.1016/J.CCELL.2020.02.002
PDBe
6I1S
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| Q04771 | ACVR1, ACVRLK2 | SPODOPTERA FRUGIPERDA | HUMAN | ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LIKE KINASE2,ALK-2,SERINE/THREONINE-PROTEIN KINASE RECEPTOR R1,SKR1,TGF-BSUPERFAMILY RECEPTOR TYPE I,TSR-I | HUMAN | ACTIVIN RECEPTOR TYPE I,ACTR-I,ACTIVIN RECEPTOR-LI ... | Mutations | |
| P62942 | FKBP1A, FKBP1, FKBP12 | ESCHERICHIA COLI BL21(DE3) | HUMAN | PPIASE FKBP1A,12 KDA FK506-BINDING PROTEIN,FKBP-12,CALSTABIN-1,FK506-BINDING PROTEIN 1A,FKBP-1A,IMMUNOPHILIN FKBP12,ROTAMASE | HUMAN | PPIASE FKBP1A,12 KDA FK506-BINDING PROTEIN,FKBP-12 ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402