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GENERAL
TITLE
DISCOVERY OF THE SECOND GENERATION ROR GAMMA INHIBITORS COMPOSED OF AN AZOLE SCAFFOLD.
DATE LAST MODIFIED
27 Mar 2019
RELEASE
6 Mar 2019
OBSOLETE
CLASSIFICATION
NUCLEAR PROTEIN/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.35
RESOLUTION RANGE LOW
72.56
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.8B01567
PDBe
--
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
P51449 RORG ESCHERICHIA COLI HUMAN RETINOID-RELATED ORPHAN RECEPTOR-GAMMA HUMAN
RETINOID-RELATED ORPHAN RECEPTOR-GAMMA
Mutations
Q9Y618 NCOR2 ESCHERICHIA COLI HUMAN SMRT HUMAN
SMRT
Mutations
P51449 RORG ESCHERICHIA COLI HUMAN RETINOID-RELATED ORPHAN RECEPTOR-GAMMA HUMAN
RETINOID-RELATED ORPHAN RECEPTOR-GAMMA
Mutations
Q9Y618 NCOR2 ESCHERICHIA COLI HUMAN SMRT HUMAN
SMRT
Mutations
P51449 RORG ESCHERICHIA COLI HUMAN RETINOID-RELATED ORPHAN RECEPTOR-GAMMA HUMAN
RETINOID-RELATED ORPHAN RECEPTOR-GAMMA
Mutations
Q9Y618 NCOR2 ESCHERICHIA COLI HUMAN SMRT HUMAN
SMRT
Mutations
P51449 RORG ESCHERICHIA COLI HUMAN RETINOID-RELATED ORPHAN RECEPTOR-GAMMA HUMAN
RETINOID-RELATED ORPHAN RECEPTOR-GAMMA
Mutations
Q9Y618 NCOR2 ESCHERICHIA COLI HUMAN SMRT HUMAN
SMRT
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402