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GENERAL
TITLE
RECOGNITION OF THE AMYLOID PRECURSOR PROTEIN BY HUMAN GAMMA-SECRETASE
DATE LAST MODIFIED
29 Jul 2020
RELEASE
23 Jan 2019
OBSOLETE
CLASSIFICATION
MEMBRANE PROTEIN
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
2.6
RESOLUTION RANGE LOW
2.6
PUBMED ID
DOI
10.1126/SCIENCE.AAW0930
PDBe
--
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonyms | Actions | ||
|---|---|---|---|---|---|---|---|---|
| Q92542 | NCSTN, KIAA0253, UNQ1874/PRO4317 | HOMO SAPIENS | HUMAN | -- | HUMAN | -- | Mutations | |
| P49768 | PSEN1, AD3, PS1, PSNL1 | HOMO SAPIENS | HUMAN | PS-1,PROTEIN S182 | HUMAN | PS-1,PROTEIN S182 | Mutations | |
| Q96BI3 | APH1A, PSF, CGI-78, UNQ579/PRO1141 | HOMO SAPIENS | HUMAN | APH-1A,APH-1ALPHA,PRESENILIN-STABILIZATION FACTOR | HUMAN | APH-1A,APH-1ALPHA,PRESENILIN-STABILIZATION FACTOR | Mutations | |
| Q9NZ42 | PSENEN, PEN2, MDS033 | HOMO SAPIENS | HUMAN | PRESENILIN ENHANCER PROTEIN 2 | HUMAN | PRESENILIN ENHANCER PROTEIN 2 | Mutations | |
| P05067 | APP, A4, AD1 | HOMO SAPIENS | HUMAN | ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AMYLOIDPRECURSOR PROTEIN,AMYLOID-BETA PRECURSOR PROTEIN,CEREBRAL VASCULARAMYLOID PEPTIDE,CVAP,PREA4,PROTEASE NEXIN-II,PN-II | HUMAN | ABPP,APPI,APP,ALZHEIMER DISEASE AMYLOID PROTEIN,AM ... | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402