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GENERAL
TITLE
IDENTIFICATION OF NOVEL, POTENT AND SELECTIVE GCN2 INHIBITORS AS FIRST-IN-CLASS ANTI-TUMOR AGENTS
DATE LAST MODIFIED
30 Oct 2019
RELEASE
9 Oct 2019
OBSOLETE
CLASSIFICATION
TRANSFERASE/TRANSFERASE INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 61 2 2
RESOLUTION RANGE HIGH
2.4
RESOLUTION RANGE LOW
48.43
PUBMED ID
DOI
10.1021/ACSMEDCHEMLETT.9B00400
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonymsActions
Q9P2K8 EIF2AK4, GCN2, KIAA1338 UNIDENTIFIED BACULOVIRUS HUMAN EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 4,GCN2-LIKE PROTEIN,EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHAKINASE 4,GCN2-LIKE PROTEIN HUMAN
EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA K ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402