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GENERAL
TITLE
DISCOVERY OF NOVEL SMALL-MOLECULE INHIBITORS OF PD-1/PD-L1 AXIS THAT PROMOTES PD-L1 INTERNALIZATION AND DEGRADATION
DATE LAST MODIFIED
27 Apr 2022
RELEASE
26 Jan 2022
OBSOLETE
CLASSIFICATION
IMMUNOSUPPRESSANT
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
2.42
RESOLUTION RANGE LOW
23.472
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.1C01682
LIGANDS
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q9NZQ7 CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 ESCHERICHIA COLI HUMAN
HPD-L1,B7 HOMOLOG 1,B7-H1
Mutations
Q9NZQ7 CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1 ESCHERICHIA COLI HUMAN
HPD-L1,B7 HOMOLOG 1,B7-H1
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402